Regional hyperthermia is used to heat up tumor material causing its metabolism to break down. Tumors do not tolerate temperatures over 41° centigrade. Because of their primitive blood supply, tumors are not able to easily divert heat. The metabolism of tumor cells is different to that of healthy cells. This makes them a target for regional hyperthermia. Using a high power hyperthermia applicator, areas where tumors are present can be targeted. Regional hyperthermia uses short radio waves that penetrate deep into the tissue, heating it up. Healthy cells can easily divert this heat. Cancer cells experience a build-up in heat, which leads to an inadequate supply of oxygen and a depletion of nutrients in the tumor.