Ivonne O’Naturally interviews Infusio founder Philip Battiade about the power of exosomes.

Exosomes

Exosomes are being heralded as the next frontier of cell therapy. While not being cells at all, they play a vital role in the communication and rejuvenation of all the cells in our body. Science has shown that the cell-to cell communication is important in maintaining a healthy cellular terrain. Age, chronic disease, environmental factors and genetic disorders can interfere with how our stem cells communicate with other cells, thus disrupting the healing process. Exosomes play a key role in the regulation of these communication processes.

What are Exosomes?

Exosomes are so-called extracellular vesicles, or small bubbles, released from cells, especially from stem cells. They act as shuttles for certain genetic information and proteins to other cells. They allow for cell-to-cell communication, transporting molecules that are important regulators of intracellular information between close and distant cells. They carry information from place to place with different functions and purposes telling cells how and when to react.

What is Exosome Therapy?

Research has given us a valuable insight into the practical functionality of exosomes. By exposing the cells of an older organism to those of a younger organism we can see that exosomes from the young stem cells are responsible for rejuvenating the older cells. This healing mechanism can now be used in regenerative medicine.

A degenerative disease comes from a continuous deterioration of cells, affecting tissues or organs. While stem cells are usually responsible for the rejuvenation of the cells, external factors may hinder the stem cells in this function. They may not be able to supply all the information needed. Supporting their function with external exosomes could have a greater positive effect, by providing new pieces of information to support the healing process.

Who May Benefit From Exosome Therapy?

Within the Infusio Concept, exosomes may help regulate processes within the body. Patients with Lyme disease, chronic inflammation, autoimmune disease and other chronic degenerative diseases may benefit from including exosomes in their treatment regimen. Exosomes may also be beneficial as part of an anti-aging therapy. Patient with degenerative joint disease have also benefitted from the use of exosomes. For more information, or to see if exosome therapy could help you, please contact us at (888) 605-6579

Exosomes and Lyme Disease

Lyme Disease is a very complex disease, caused by the Borrelia burgdorferi bacteria, which compromises the immune system. Tick-borne disease can also come with multiple co-infections. A combination of factors causes the onset of illness as immune system functions become disrupted leading to diminishing cellular health, immune function, metabolic function and dramatically increasing inflammation. Many Lyme patients often have dysfunction of the mast cells, increasing their inflammatory response. Inflammation is a central player in most neurodegenerative diseases as well. Incorporating exosomes into a multi modality treatment regimen may help break the inflammatory cycle and provide the body with necessary cellular information to facilitate healing.

Resources

Human Mesenchymal Stem Cell-Derived Microvesicles Prevent the Rupture of Intracranial Aneurysm in Part by Suppression of Mast Cell Activation via a PGE2-Dependent Mechanism
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287411/

 

The Transitioning from Stem Cells to Stem Cell-Derived Exosomes for Treatment of Neurodegenerative Conditions
http://www.remedypublications.com/annals-of-stem-cell-research-and-therapy/articles/pdfs_folder/ascrt-v2-id1017.pdf

 

Mesenchymal Stem Cell-Derived Exosomes: New Opportunity in Cell-Free Therapy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071792/

 

Recent Advances of Exosomes in Immune Modulation and Autoimmune Diseases
https://www.ncbi.nlm.nih.gov/pubmed/27259064

 

Extracellular Vesicles: Evolving Contributors in Autoimmunity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396963/

 

A Potent Immunomodulatory Role of Exosomes Derived from Mesenchymal Stromal Cells in Preventing cGVHD
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286548/

 

Effects of Mesenchymal Stem Cell-Derived Exosomes on Experimental Autoimmune Uveitis
https://www.nature.com/articles/s41598-017-04559-y

 

Exosomes: A Novel Strategy for Treatment and Prevention of Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468768/

 

Emerging Role of Exosomes in the Joint Diseases
https://www.karger.com/Article/FullText/491469

 

Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519012/

 

Mesenchymal Stem Cells-Derived Exosomes: A Possible Therapeutic Strategy for Osteoporosis
https://www.ncbi.nlm.nih.gov/pubmed/29623851

 

Mesenchymal Stem Cells-Derived Exosomes are More Immunosuppressive than Microparticles in Inflammatory Arthritis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835945/

 

Macrophage Immunomodulation: The Gatekeeper for Mesenchymal Stem Cell Derived-Exosomes in Pulmonary Arterial Hypertension?
https://www.mdpi.com/1422-0067/19/9/2534/htm

 

Exosome-RNA.com Articles
https://www.exosome-rna.com/tag/autoimmune-diseases/

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